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Their main point is that all studies that are retrospective ‘particularly those based on administrative databases’ are fraught with bias. Undoubtedly it is true that any study can be biased, or wrong by chance, but one has to describe what this bias would be, so each point can be individually judged for its merit. Blanket statements about bias are senseless. This is a point we dealt with over 10 years ago, when we dissected all biases that had been brought forward in a paper in the New England Journal of Medicine [1]. None held true. Since then, many more studies have come out, with very different designs, ranging from nested case control studies in the UK General Practioners’ Research Database (GPRD) [2], to cohort studies linking national databases in Denmark [3], to case Canada Goose Resolute Parka
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